Fri May 09 2025

39 articles - From Friday May 02 2025 to Friday May 09 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

J Crohns Colitis

Association between inflammatory bowel disease, current therapies, and cardiovascular events: a review and meta-analysis of data from 2.2 million individuals.

There is an increased risk of MI, IHD, CVA and MACE in IBD patients. Management of IBD needs to consider these risks and how it may be adjusted when selecting advanced therapies.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Assessing the adherence and acceptability to iron and folic acid versus multiple micronutrient supplements during pregnancy: A cluster-randomized non-inferiority trial in Cambodia.

Both IFA and MMS were highly acceptable, yet adherence to MMS was superior to IFA. These findings support the transition from IFA to MMS in Cambodia.

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Dairy intake, plasma metabolome, and risk of type 2 diabetes in a population-based cohort.

In this cohort of Swedish adults, high intakes of nonfermented milk and cheese are positively associated with risk of T2D, although high intakes of fermented milk, cream, and butter are inversely associated. Metabolomics provides novel insights into understanding the metabolic pathways of these associations.

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Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study.

Maternal diet at pregnancy and omega-3 intake may support long-term cognitive development in children and adolescents.

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Nitrate and nitrite food composition database: an update and extensive deep dive.

The newly developed database and automated nitrate/nitrite calculator will facilitate future nutritional health studies to estimate dietary nitrate/nitrite exposure more accurately and efficiently and determine the resulting health implications.

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One-carbon metabolism, insulin resistance, and fecundability in a Singapore prospective preconception cohort study.

Our findings suggest that higher folate and lower homocysteine levels, which reflected the interlinked folate and methionine cycles, was associated with higher fecundability in preconception women with lower IR, but less so in those with higher IR. Clinical Trial Registry number and website where it was obtained NCT03531658, /study/NCT03531658.

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The Association of Early Pregnancy Vitamin D and BMI Status with Composite Adverse Pregnancy Outcomes: an Ancillary Analysis of the Vitamin D Antenatal Asthma Reduction Trial.

While vitamin D supplementation did not reduce APO risk, higher early pregnancy 25(OH)D concentrations were associated with lower odds of APOs in participants with BMI <25 kg/m 2 . These findings highlight the potential importance of higher early pregnancy 25(OH)D concentrations, particularly among those with normal BMI, in reducing APO risk.

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Inflamm Bowel Dis

Clinical Utility and Accuracy of Point-of-Care Testing for Anti-TNF Drug Monitoring and Loss of Response.

Serum ADL and IFX POCT concentrations are comparable to ELISA and associated with LOR, indicating its clinical utility.

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J Crohns Colitis

Differential effects of tofacitinib on macrophage activation contribute to lack of response in ulcerative colitis patients.

We conclude that resistance to tofacitinib is mediated by the hyperactivation of myeloid cells and we identify IL-10-dependent macrophages as one cellular subset contributing to this resistance.

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ECCO topical review on predictive models on IBD disease course and treatment response.

This topical review offers practice recommendations and guidance for future predictive models on IBD disease course and treatment response including their implementation in clinical practice.

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Early Intestinal Ultrasound Response to Biologic and Small Molecule Therapy is Accurate to Predict Treat-To-Target Endoscopic Outcomes in Children with Ulcerative Colitis: Results from the Prospective Super Sonic-UC Study.

Combining non-invasive biomarkers of BWT and the MUC on IUS, and FC, is a feasible tight control monitoring strategy in children with UC that is predictive of endoscopic outcomes. Larger, multicenter validation studies are needed to understand how an IUS and FC monitoring strategy may improve outcomes in children with UC.

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Spatial mapping and geographic variation of inflammatory bowel disease in Canada: A population-based study.

Results demonstrated significant geographic variations in the prevalence of IBD in Canada. Evidence suggests differences in prevalence between regions are primarily driven by individual demographics rather than geographical characteristics.

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Liver Transpl

Implementation of intra-operative distal splenic artery ligation for portal inflow modulation in adult living donor Liver Transplantation.

There was decreased incidence of small for size syndrome (SFSS) (p<0.05) with no incidence of grade-C SFSS and lower 90 day-mortality in the SAL group (p<0.01). Intra-operative distal SAL significantly reduces portal hyper-perfusion, thereby reducing early allograft dysfunction, small for size syndrome, morbidity and improved one year survival.

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Pancreas

A Novel Deep Learning-based Pathomics Score for Prognostic Stratification in Pancreatic Ductal Adenocarcinoma.

The pathomics score serves as a cost-effective and precise prognostic tool, functioning as an independent prognostic indicator that enables precise stratification and enhances the prediction of prognosis when combined with traditional pathologic features. This advancement has the potential to significantly impact PDAC treatment planning and improve patient outcomes.

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Abdominal Pain Following Total Pancreatectomy with Islet Autotransplantation.

As more patients undergo TPIAT, we must plan for and address the associated causes of abdominal pain that result from alterations in anatomy and physiology, both in the short and long term.

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Impact of Etiology on Predictive Models for Acute Pancreatitis Severity: A Retrospective Study.

This study sheds new light on early-stage AP severity prediction, emphasizing the association between predictors, etiology, and clinical outcomes.

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Local Recurrence and Survival Outcomes after Portal Vein/Superior Mesenteric Vein Separation without Resection Preceding Neoadjuvant Therapy for Pancreatic Ductal Adenocarcinoma.

Separation of the PV/SMV in NAT+/PVC+ patients did not enhance local recurrence or aggravate OS if PV/SMV invasion was not suspected intraoperatively. Therefore, an attempt to separate the PV/SMV is acceptable.

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Pancreatic Neuroendocrine Tumors-A Descriptive Study of the Presenting Features in a 20-Year Surgical Resection Cohort at a Tertiary Institution.

This study provides a comprehensive description of pNET characteristics in a large surgical cohort. Findings highlight the predominance of nonfunctional tumors and the importance of imaging and EUS in diagnosis. The data can aid in inter-institutional comparisons and enhance understanding of pNETs, contributing to improved patient management and future research.

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Prognostic Properties of KRAS Gene Mutation Subtypes in Resected Pancreatic Ductal Adenocarcinoma.

Next-generation sequencing of the KRAS subtype in resectable PDAC tumors shows that the KRAS G12D/G12V subtypes confer a worse prognosis compared with wild-type KRAS tumors.

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Serum Phosphate is a Biomarker for In-hospital and 30-day Mortality in Patients With Acute Pancreatitis Based on the MIMIC-IV Database.

A linear positive relationship was found between serum phosphate and in-hospital and 30-day mortality in AP. Serum phosphate was associated with in-hospital and 30-day mortality in AP. Our results could be used for screening out those AP patients with a higher risk of worse outcomes.

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Transcriptome Analysis of Human Pancreatic Stellate Cells Co-cultured With PAK1-Modulated Cells Revealed the Role of Cytokine Pathway in Tumor Microenvironment.

The present study provides an understanding of tumor microenvironment and involvement of inflammatory cytokines in a juxtacrine mechanism to aggravate and accelerate pancreatic adenocarcinoma.

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Pancreatology

Development and validation of a novel chronic pancreatitis pathological grade based on artificial intelligence.

This study developed a novel pathological classification, Histopathology-derived CPpG, which accurately reflects disease severity. Additionally, the non-invasive DLRS shows great potential for dynamically monitoring CP severity and evaluating pancreatic endocrine and exocrine function, as well as prognosis.

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Proposing oligo-recurrence criteria in pancreatic ductal adenocarcinoma: A stratified analysis of locoregional treatment benefits.

Results LT was performed in 79 patients (20.8 %) and not in 301 patients (79.2 %). Independent predictors of poor SAR included time to recurrence (TTR) ≤ 12 months, CA19-9 > 200 U/mL at recurrence, and multi-organ recurrence or ≥ 4 tumors (P  12 months" and "SOR with ≤3 tumors" may achieve long-term survival with LT, leading to the proposal of defining them as having "oligo-recurrence" in PDAC.

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Somatostatin analogs for resectable pancreatic neuroendocrine tumors in high-risk surgical patients: Data from a single-center cohort.

The efficacy of SSA was evaluated using the analysis of tumor growth rate (TGR). "Negative TGR 20 mm, SSA can obtain disease control with a manageable safety profile.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

A new era in understanding dietary nitrate and nitrite: comprehensive food composition database could enable evidence-based recommendations.

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Dairy consumption and higher risk of type 2 diabetes and novel metabolomic pathways.

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Inflamm Bowel Dis

AI-Assisted IBD Severity Classification: A Critical Perspective on Current Evidence and Next Steps.

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Non-Typhoidal Salmonella Infections and Inflammatory Bowel Disease Risk: New Findings and Multidimensional Perspectives for Future Research.

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The Way Forward in the Diagnosis and Treatment of IBDU in Children: A Global Perspective and Multidimensional Exploration.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Multifaceted Endoscopic Approach (Stricturotomy, Balloon Dilation, Fistulotomy, and Seton Placement) Guided by Intestinal Ultrasound to Avert Surgery in Complicated Crohn's Disease During Lactation.

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Response to the Letter to the Editor: "AI-Assisted IBD Severity Classification: A Critical Perspective on Current Evidence and Next Steps".

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Understanding Pouch-Related Fistulae: Don't Lose Track of Time.

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Pancreas

A Case of Cystic Pancreatic Neuroendocrine Tumor Misdiagnosed as Intraductal Papillary Mucinous Neoplasm.

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Metronidazole Exposure Has Limited Impact on Clinical Outcomes in Pancreatic Cancer.

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Pancreatic Solid Pseudopapillary Neoplasms in Childhood.

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Prediabetes and Pancreatic Cancer Risk.

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Rare Pancreatic Neuroendocrine Tumor With Hyalinization Exhibiting Atypical Imaging Features: A Case Report.

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Uncommon Presentation of a Rare Entity: Acute Pancreatitis Due to Diffuse Pancreatic Arteriovenous Malformation.

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Letters&Replies

Letters to the editors and authors’ replies

Pancreatology

Technical success of double-balloon enteroscopy - Endoscopic retrograde cholangiopancreatography in patients with pancreaticojejunostomy anastomotic strictures post-pancreatoduodenectomy.

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